HPV testing in first-void urine provides sensitivity for CIN2+ detection comparable to a physician-taken smear or brush-based self-sample: cross-sectional data from a triage population

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Leeman et al, BJOG - International Journal of Obstetrics and Gynecology 2017 (Publication)

Aim: Compare the sensitivity of high risk HPV in self-collected urine samples in the morning , and later on, brush-based self-samples, and clinician-taken smears for detecting cervical intraepithelial neoplasia grade 2+(CIN2+) in a colposcopic referral population.

Partners: DDL Diagnostic Laboratory (The Netherlands), Faculty of Medicine - University of Barcelona (Spain), Institut de Salit Global de Barcelona (Spain), Erasmus Medical Centre (The Netherlands)

Results: CIN2+ detection using HPV testing of first void urine is convenient and shows similar sensitivity and specificity to clinician taken samples or brush-based self-samples, with CIN2+ state as a reference.

https://www.ncbi.nlm.nih.gov/pubmed/28391609

 

Additionally, the following posters below report the interim results that led to the publication:

1. First-void urine and physician-taken smear show similar sensitivity for the detection of CIN2+ lesions

Leeman et al, ECCMID Amsterdam, 2016 (Poster)

Aim: Compare self-collected urine, brush-based self-samples (SS) and physician-taken smears (PTS) for HPV detection and variation between morning collection (U1) and collection during the day (U2).

Partners: DDL Diagnostic Laboratory (The Netherlands), Faculty of Medicine - University of Barcelona (Spain)         

Results: CIN2+ detection using HPV testing in first-void urine is feasible, with sensitivity similar to the sensitivity and specificity to PTS and SS. No advantage in testing morning first-void urine over first-void from later during the day was observed.

 

2. The detection of hrHPV-infection of the cervix using first-void urine in women with an abnormal pap-smear

Leeman et al, International Papillomavirus Conference, Lisbon, 2015 (Poster)

Aim: Determine the sensitivity and specificity of morning first-void urine for HPV detection compared to first-void urine from later during the day and to study the correlation between HPV detection using self-collected urine samples and physician-taken cervical smears.

Partners: DDL Diagnostic Laboratory (The Netherlands), Faculty of Medicine - University of Barcelona (Spain)         

Results: Detection of CIN2+ lesions through HPV-testing in first-void urine seems feasible, with a sensitivity and specificity similar to the physician-taken smears. The data suggest that there is no advantage in testing morning first-void urine over first-void from later during the day.