First void (or first catch or first pass) urine, typically referred to the first 20 mL of urine flow, is collected at any time of the day. This fraction has shown to contain higher concentrations of Human Papillomavirus (HPV) and sexually transmitted infections (STI)-related DNA. First-void urine is also a promising source to detect biomarkers for prostate cancer. For more information visit our first-void urine page.
Novosanis has compiled answers to the most common questions. If you do not see the answer to your question, feel free to reach out to us.
No, not all urine fractions are the same. There is a range of terminology used in the field to characterize the different times and fractions of urine collection. Read our Pee-Glossary to know more.
Collecting a first-void urine sample (first 20 mL of urine) with a classic urine cup can be awkward, messy and inconvenient for the user. The volume of the collected sample is also difficult to control, leading to undesired variation in downstream analysis. The unique design of Colli-Pee® allows for standardized and volumetric collection of first-void urine, without the need to interrupt urine flow. To know more about the benefits of the Colli-Pee® device, visit our products page.
Anytime. There is no difference between first-void urine collected with Colli-Pee® in the morning or during the day.
Colli-Pee® can be used in 3 different pee positions, and is therefore suitable for use with different toilet types or urinals.
Yes. One of the main advantages of Colli-Pee® is that it is very well suited for urine collection at home and for postal delivery, offering the opportunity to reach a wider population. For more information , visit our home collection page.
The Colli-Pee® device is registered in several countries. Availability of the variants depends on your location.
Contact us to know the registration status in your region.
All neat variants of Colli-Pee® have a shelf life of 5 years. Colli-Pee® Small Volumes with UCM and Colli-Pee® 20 mL with UCM have a shelf life of 2 years. For more information read our urine stabilization page.
The media in our device is manufactured in a qualified and controlled environment and meets product specifications prior to release. The media formulation contains a component, which in certain conditions may create small visible particulates. This particulate formation is expected and has no demonstrated impact on the performance of our media. However, if the media is cloudy in appearance, we recommend that you discard that collection device as there could be a contaminant.
For more information on Colli-Pee® prices, contact your Novosanis sales responsible, or contact Novosanis directly.
Novosanis is ISO13485 certified by SGS Belgium. Our quality system is fully compliant with the requirements of ISO13485 quality standards for manufacturers of medical devices. Novosanis' Colli-Pee® device is CE-marked and FDA listed, with registered trademarks® in several countries. Contact us to know the registration status in your region.
In the period between collection and processing, analytes in urine can be degraded. Novosanis has developed Urine Conservation Medium (UCM®), a non-toxic urine stabilization chemistry that will keep the DNA in your urine sample stable at room temperature, for a period of at least 7 days. Furthermore, to extend the preservation coverage to other analytes (RNA, EV, cfDNA) a new preservative, UAS is currently in development. Read our urine stabilization solutions page for more information.
Colli-Pee® can be prefilled with Novosanis’ UCM, to allow preservation of DNA in urine.
To extend the preservation coverage to other analytes (RNA, EV, cfDNA) we introduce Colli-Pee® containing UAS TM.
Read our urine stabilization solutions page for more information.
Storage conditions for Colli-Pee® (20 mL) tubes containing UCM®), after first-void urine collection varies:
- Short-term storage at room temperature: 7 days
- Short- to mid-term storage at 4°C: 14 days
- Mid-term storage at -20°C: 7 to 90 days
Storage conditions for Colli-Pee® tubes containing UASTM, after first-void urine collection varies:
Short-term storage at room temperature: 7 days
For more information read our urine stabilization page.
Optimal preservative to sample ratio depends on the type of preservative.
Our data shows:
- UCM® is 1:3 Preservative to sample ratio for optimal preservation performance
- UASTM is 2:5 Preservative to sample ratio for optimal preservation performance
Read our urine stabilization solutions page for more information.
Colli-Pee® can be used in various applications, including detection of sexually transmitted infections (STIs) as well as cancer biomarkers.
Read more about Colli-Pee® applications.
As urine collection is absolutely non-invasive it is very suitable for multi-omic testing, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics. Several analytes can be found in urine such as DNA, RNA, proteins, metabolites. For more information visit our first-void urine page.
Several studies have shown first-void urine collected with Colli-Pee® with UCM can improve detection of sexually transmitted infections (STIs), including Human Papillomavirus (HPV).
Read more about the infectious disease applications.
When appropriately sampled, stored, and processed, first-void urine is a particularly valuable liquid biopsy source for primary Human Papillomavirus (HPV) testing. Colli-Pee® has been used previously in various studies around cervical cancer screening, and has been shown to be an optimal sample collection device in this setting. Read our blog about urine based cervical cancer.
Several studies have shown that women prefer easy, and non-invasive techniques that are not clinician dependent. Urine as a sample type is well-accepted, and given its ability to detect Human Papillomavirus (HPV), has the potential to reach a wider population, especially women who do not participate in screening. Read more about urine as a preferred sample type.
Although Colli-Pee® is perfectly suited to be used by all genders, no publications are available to date. Please contact us if you would like to set up a trial.
Yes. Colli-Pee® can facilitate and standardize detection and stabilization of urinary biomarkers in prostate cancer research. Colli-Pee® is already used by Dx companies. Further research is ongoing through our URODETECT project.
Urine sampling is absolutely non-invasive and allows for home self-sampling. Additionally, collection is not limited by health status of patient, poses no risk for bloodborne pathogen transmission, and allows high volume allowing multi-omic testing. Read more about the benefits of urine as a liquid biopsy.
Yes. cfDNA can be detected in various biological fluids, including cerebrospinal fluid, plasma, saliva, seminal plasma, serum and urine.
Yes, urinary extracellular vesicles (UEVs) entering from the kidneys and urinary tract can be detected in urine collected with Colli-Pee®.
When appropriately sampled, stored, and processed, first-void urine is a particularly valuable liquid biopsy source for primary Human Papillomavirus (HPV) testing and for analysis of molecular biomarkers including methylation.