Colli-Pee and first-void urine
Colli-Pee for standardized and volumetric collection of first-void urine.
- Urine sampling: an emerging sample type
- Urine Fractions – first-void urine
- When to use first-void urine
Urine sampling: an emerging sample type
Blood might be the most common liquid biopsy, but blood sampling has several limitations:
- It contains a relatively high and complex protein repertoire, that can interfere with biomarker measurements
- It is relatively invasive
- It can pose a risk of infection for both the patient and the caregiver (1,2)
Alternatively, urine sampling has multiple benefits:
- Urine is easily accessible and available in larger quantities
- Urine sampling is non-invasive
- Urine can easily be collected at home by an individual
Urine fractions - First-void urine
First-void urine, also known as first-catch or first-pass urine is collected at any time of the day and is typically referred to the first 20 mL of urine flush. A first-void urine specimen has shown to contain higher concentrations of sexually transmitted infections (STI)-related DNA than other fractions (3,4). Additionally, first-void urine can be important to identify cancer biomarkers (1).
"I am convinced that the clinical and diagnostic information present in a first-void urine sample still is greatly underestimated. We confirmed that first-void urine is an interesting sample to monitor HPV vaccination programs; possibilities in cervical cancer screening programs are being explored. The non-invasive character of urine sampling, with option of home collection, will definitely help to enroll underserved women in cervical cancer screening and follow-up programs across the world."
Prof. Alex Vorsters
HPV VAXINFECTIO (University of Antwerp)
When to use first-void urine
For STIs, first-void urine contains more DNA and RNA particles, as well as other analytes than other fractions such as a random or midstream urine sample. For example, several studies have shown that a first-void urine specimen can improve detection of STIs including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG) in men (4).
First-void urine also contains a significantly higher concentration of Human Papillomavirus (HPV) DNA than subsequent fractions (3). Strains of HPV are known to be a major cause of cervical cancer in women.
For urological cancers particularly, a urine specimen is in many situations the preferred liquid biopsy source. Specific DNA, RNA, proteins, and metabolites for prostate cancer have also been identified in first-void urine (5).
Given the importance of capturing first-void urine for improved accuracy and test results, Novosanis developed Colli-Pee®, a first-void urine collection device. The unique design of the device allows easy collection of first-void urine and improved sample stability, which can be challenging and difficult with a regular urine cup.
*Some Novosanis products are in development or not available in all geographic regions. Contact us to know the registration status in your region.