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Collecting first-void urine or first-catch urine (initial urine flow) in a regular urine container is not standardized and can be awkward, messy and inconvenient for the user. Men find it difficult to stop urine flow midway, while women can have difficulties in correctly positioning the container. 

The Colli-Pee 20 mL variant, which is CE Marked, is designed to allow easy and efficient collection of first-void urine. The unique inherent float system of the device captures first-void urine, and creates a passage through which superfluous urine can pass directly into the toilet, without interrupting urine flow.

Colli-Pee allows collection of first-void urine

First-void urine can be used to detect infectious diseases including several sexually transmitted infections (STIs) such as Human Papillomavirus (HPV), Chlamydia, Gonorrhea, Mycoplasma genitalium and Trichomonas as well as some cancer biomarkers.

For detection of STIs, such as HPV, the primary cause of cervical cancer, a first-void urine sample is required as this fraction contains more HPV DNA particles than subsequent fractions, improving diagnostic sensitivity and specificity compared to a midstream sample (1). Alongside STIs, some cancer types, such as prostate cancer, the use of first-void urine can improve detection (2). 

To know more urine as a preferred sample type for HPV detection, read our blog.

Urine Stability

Analytes present in urine can act as a tool to improve detection of infectious diseases, to uncover the molecular landscape of tumors in cancer and to research the human microbiome.

However, given the possibility of microbial proliferation in urine as well as the labile nature of host analytes (extracellular vesicles, RNA, cell free DNA…) at the point of sample collection and transport, methods to stabilize urine samples are necessary.  

In clinical practice, on the one hand, where samples are often collected at different hospital sites and sent to central laboratories for testing, a preservative would allow for sample batching and transport at room temperature.

Alternatively, in studies searching for urinary analytes, which are rapidly expanding in cohort sizes, a preservative would allow for at-home collection and facilitate large-scale recruitment.

Currently, the Colli-Pee 20 mL can be prefilled with the non-toxic Novosanis proprietary Urine Conservation Medium (UCM), which allows preservation of urine. Novosanis and its wider team are working on additional stabilization solutions for different urinary analytes to allow for improved storage and transport of urine at ambient temperature.

The combination of the Colli-Pee platform with a preservative for urine stabilization is game-changing in the field of urine-based diagnostic testing.

Instructions for use

IFU N00055 - Colli-Pee 20 mL (June 2019)

IFU N00176 - Colli-Pee 20 mL containing UCM preservative (May 2019)

IFU N00238 - Colli-Pee 20 mL with transportation clip (May 2019)


1. Vorsters A, Van den Bergh J, Micalessi I, Biesmans S, Bogers J, Hens A, De Coster I, Ieven M, Van Damme P. Optimization of HPV DNA detection in urine by improving collection, storage, and extraction. Eur J Clin Microbiol Infect Dis. 2014 Nov;33(11):2005-14. doi: 10.1007/s10096-014-2147-2. Epub 2014 Jun 12. PubMed PMID: 24916950.

2. Theodorescu D, Schiffer E, Bauer HW, Douwes F, Eichhorn F, Polley R, Schmidt T, Schöfer W, Zürbig P, Good DM, Coon JJ, Mischak H. Discovery and validation of urinary biomarkers for prostate cancer. Proteomics Clin Appl. 2008 Mar 7;2(4):556-570. PubMed PMID: 19759844; PubMed Central PMCID: PMC2744126.

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*Some Novosanis products are in development or not available in all geographic regions. Contact us to know the registration status in your region.