A Randomized Comparison of Different Vaginal Self-sampling Devices and Urine for Human Papillomavirus Testing-Predictors 5.1
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Cadman et al., 2021
Aim: To compare high-risk HPV sensitivity and positivity rates of four different self-collected vaginal samples (dry flocked swab, Dacron swab, HerSwab and Qvintip) and a urine sample using Colli-Pee® in a colposcopy referral population.
Affiliations:
- Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London
- Colposcopy Department, Royal London Hospital, London
- NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College, London
Summary: In total, 505 pairwise collected vaginal and urinary self-samples were considered suitable for further downstream analysis. Overall, similar positivity rates and sensitivities for CIN2+ and CIN3+ cervical lesions were seen for the dry-flocked swab, Dacron swab and the Colli-Pee® while lower values were seen for the HerSwab and the Qvintip. No clear user preferences were seen between devices, but women found urine easiest to collect, and were more confident they had taken the sample correctly