Marcus et al, 2021
Aim: To evaluate HPV detection in urine for the first time by the Xpert HPV test on the GeneXpert platform.
Affiliations: Rutgers New Jersey Medical School and Cancer Institute of New Jersey (CINJ), Newark, NJ, USA, Albert Einstein College of Medicine, Bronx, NY, USA.
Summary: A total of 40 women were enrolled and consented their participation in the study, 30 who were referred to colposcopy because of a prior positive screening test and 10 undergoing routine cervical screening. Xpert HPV testing of urine appears feasible and reproducible but its analytic sensitivity, especially for HPV31, 33, 35, 52, and 58 strains that together account for 15% of cervical cancer cases, needs improvement. One possible strategy to increase analytic sensitivity warrants investigation of first-void urine.