First-void urine as a non-invasive liquid biopsy source to detect vaccine-induced human papillomavirus antibodies originating from cervicovaginal secretions

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Van Keer et al, Journal of Clinical Virology, 2019 (Publication)

Aim: To investigate the presence of HPV-specific antibody transudates from systemic circulation in first-void urine of (un)vaccinated subjects and the agreement with paired sera.

Partners: University of Antwerp, VAXINFECTIO, DKFZ, Multidisciplinary Breast Clinic, Unit Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Antwerp University Hospital Antwerp (Belgium), MIPRO, PPES, CHERMID.

Results: The results provide first proof that vaccine-induced HPV antibodies are detectable in the first-void urine of young women. Moreover, significant positive correlations were observed between HPV6/11/16/18-antibodies in first-void urine and paired sera.