First-void urine as a non-invasive liquid biopsy source to detect vaccine-induced human papillomavirus antibodies originating from cervicovaginal secretions

Van Keer et al., 2019

Aim: To investigate whether the presence of HPV-specific antibody transudates from systemic circulation in first-void urine of (un)vaccinated subjects and the agreement with paired sera.

Affiliations: Centre for the Evaluation of Vaccination (CEV) and the CHERMID and Vaccine & Infectious Disease Institute (VAXINFECTIO) of the University of Antwerp; Infections and Cancer Epidemiology Group, German Cancer Research Center (DKFZ); Multidisciplinary Breast Clinic of the Antwerp University Hospital; Molecular Imaging, Pathology, Radiotherapy, Oncology (MIPRO) of the University of Antwerp; Laboratory of Protein Science, Proteomics & Epigenetic Signalling (PPES) of the University of Antwerp; Centre for Statistics, of the Hasselt University

Summary: The present study shows that vaccine-induced HPV antibodies are detectable in the first-void urine of young women. Moreover, significant positive correlations were observed between HPV6/11/16/18-antibodies in first-void urine and paired sera. Further optimization and validation are required to demonstrate its potential use in epidemiological studies and follow-up of HPV vaccination.

First-void urine as a non-invasive liquid biopsy source to detect vaccine-induced human papillomavirus antibodies originating from cervicovaginal secretions