IWT study
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Aim: Comparison Colli-Pee™ device to regular urine collector
Partners: University of Antwerp (VAXINFECTIO, Product Development), Novosanis nv
Results were presented on a poster at the IPV conference 2015, Lisbon.
22 HPV-positive women were included and each collected 8 UCM-preserved urine samples on 4 consecutive days (morning and late afternoon), using either the Colli-Pee™ or a regular urine cup. Therefore, 172 first-void urine samples were obtained, of which 88 Colli-Pee™ and 88 urine cup.
Main results included:
- Positive samples sets for 14 women, negative sample sets for 4 women, one out of eight samples negative for 2 women, six out of eight samples negative for 1 woman.
- No impact of collection time was found on copies of HPV16, all detected HPV genotypes and human DNA
- Significant impact of collection method: more copies HPV16/HPV DNA/human DNA where found in Colli-Pee™ collected first-void urine
These results further confirm that when an appropriate preservative and DNA extraction method is used, urine is a reliable and reproducible sample for HPV DNA testing. A first-void urine collection device may help to enhance HPV DNA detection in urine, independent the FV is taken from the first urine of the day or from urine provided later in the day.
