Urine testing to monitor the impact of HPV vaccination in Bhutan and Rwanda

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Franceschi et al., 2016

Aim: Bhutan (2010) and Rwanda (2011) were the first countries in Asia and Africa to introduce national, primarily school-based, human papillomavirus (HPV) vaccination programmes. In order to obtain the earliest indicators of vaccine effectiveness, a two school-based HPV urine surveys in Rwanda and Bhutan were performed in 2013.

Affiliations:

  • International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
  • Ministry of Health of Rwanda, Kigali, Rwanda
  • Department of Obstetrics & Gynaecology, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan
  • Department of Laboratory Services, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan
  • Centre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
  • Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 Amsterdam, HV, The Netherlands

Summary: The study outcome supports the feasibility of first-void urine surveys to monitor HPV infection after vaccination. Furthermore, the study demonstrates the effectiveness of the quadrivalent HPV vaccine in women vaccinated after pre-adolescence. From a future perspective, similar first-void urine surveys with Colli-Pee® could enable monitoring of HPV vaccination effectiveness in (pre)adolescent females.

Read more about HPV detection using urine as a sample type

Urine testing to monitor the impact of HPV vaccination in Bhutan and Rwanda