Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing

Vorsters et al., 2016

Aim: This study investigated the use of urine samples, which can be collected by self-sampling at home, instead of cervical samples for follow-up of an HPV intervention trial.

Affiliations: Centre for the Evaluation of Vaccination (CEV) and the Laboratory of Medical Microbiology of the Vaccine & Infectious Disease Institute (VAXINFECTIO) at the University of Antwerp; Department of Clinical Microbiology of the Antwerp University Hospital

Summary: Eighteen initially HPV DNA-positive women participating in an HPV therapeutic vaccine trial were monitored during a three-year follow-up period resulting in a total of 172 urine samples and 85 cervical collected samples. The HPV DNA results obtained in this study are consistent with previous and subsequent urine and/or cervical results demonstrating that urine sampling may be a valid alternative to cervical samples for the follow-up of HPV intervention trials or programs.

Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing